Garlic and aged garlic extract (AGE) has been shown to help improve immune cell function and reduce the severity of infections like colds and flus (1).
In addition to boosting general immune function, studies suggest that garlic has strong anti-cancer properties. Garlic works to protect against cancer by reducing free radicals, increasing glutathione, repairing DNA, and preventing chromosomal damage, among others (2).
Studies show that aged garlic extract (AGE) can modulate immune cell distribution and increase serum levels of inflammation-fighting TNF-α and IL-6 (3). This may help reduce the development of low-grade inflammatory chronic diseases, especially related to obesity.
Aged garlic extract (AGE) has shown potential anti-allergic effects. Studies show that AGE can reduces the body’s allergic responses by modifying the function of immune cells, specifically altering the function of mast cells, basophils, and T lymphocytes to reduce the allergic cascade and inflammatory response (4).
Garlic could reduce viral infections in the upper respiratory tract, including the common cold (5). Studies suggest that garlic has antiviral effects and can specifically help reduce the risk of conditions like lung cancer (6, 7).
Gut Health Support
Garlic helps to support gut health by improving the composition of the gut microbiome (8). Studies suggest this may be specifically helpful to improve health and gut function in those with high-fat diets, as garlic also improves gut dyslipidemia (9).
Garlic has been shown to improve cardiovascular function and reduce risk of cardiovascular disease. One study suggests that garlic can reduce serum cholesterol (10). Others show that garlic supplementation reduces blood pressure in those with hypertension (11).
Studies also show that garlic has hypoglycemic effects and can reduce fasting blood sugar levels (12).
Garlic has been shown to increase exercise endurance and improve fatigue, whether related to physical exertion, fatigue from illness, or general tiredness from an unknown cause (13).
Why garlic helps fatigue is still being studied, but some research points to garlic’s ability to reduce oxidative stress, facilitate glucose metabolism, and enhance oxygenation in muscles as the mechanisms of action (14).
Low-temperature aged garlic (LTAG) and raw garlic have been shown to reduce acute stress and may moderate depression by decreasing stress hormones such as cortisol, corticotropin-releasing factor, and corticosterone (15).
The anti-inflammatory effect of garlic has been recommended to help improve sleep in those with conditions like sleep apnea (16).
- Susan S Percival, Aged Garlic Extract Modifies Human Immunity, The Journal of Nutrition, Volume 146, Issue 2, February 2016, Pages 433S–436S, https://doi.org/10.3945/jn.115.210427
- Miraghajani, Maryam et al. “Aged Garlic and Cancer: A Systematic Review.” International journal of preventive medicine vol. 9 84. 17 Sep. 2018, doi:10.4103/ijpvm.IJPVM_437_17
- Changjie Xu et al, Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial, Clinical Nutrition ESPEN, Volume 24, 2018, Pages 148-155, ISSN 2405-4577, https://doi.org/10.1016/j.clnesp.2017.11.010.
- Kyo E et al. Anti-allergic effects of aged garlic extract. Phytomedicine. 1997 Dec;4(4):335-40. doi: 10.1016/S0944-7113(97)80043-8. PMID: 23195584.
- Lissiman, Elizabeth et al. “Garlic for the common cold.” The Cochrane database of systematic reviews vol. 2014,11 CD006206. 11 Nov. 2014, doi:10.1002/14651858.CD006206.pub4
- Bayan, Leyla et al. “Garlic: a review of potential therapeutic effects.” Avicenna journal of phytomedicine vol. 4,1 (2014): 1-14.
- Jin, Zi-Yi et al. “Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population.” Cancer prevention research (Philadelphia, Pa.) vol. 6,7 (2013): 711-8. doi:10.1158/1940-6207.CAPR-13-0015
- Chen, Keyu et al. “Modulation of Allicin-Free Garlic on Gut Microbiome.” Molecules (Basel, Switzerland) vol. 25,3 682. 5 Feb. 2020, doi:10.3390/molecules25030682
- Chen, Keyu et al. “Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis.” Nutrients vol. 11,6 1225. 29 May. 2019, doi:10.3390/nu11061225
- Stephen Warshafsky et al. Effect of Garlic on Total Serum Cholesterol: A Meta-Analysis. Ann Intern Med.1993;119:599-605. [Epub ahead of print 1 October 1993]. doi:10.7326/0003-4819-119-7_Part_1-199310010-00009
- Ried, K. et al. Effect of garlic on blood pressure: A systematic review and meta-analysis. BMC Cardiovasc Disord 8, 13 (2008). https://doi.org/10.1186/1471-2261-8-13
- Hou, Li-Qiong et al. Garlic intake lowers fasting blood glucose: Meta-analysis of randomized controlled trials [online]. Asia Pacific Journal of Clinical Nutrition, Vol. 24, No. 4, Dec 2015: 575-582. Availability: <https://search.informit.com.au/documentSummary;dn=743291986410926;res=IELAPA> ISSN: 0964-7058. [cited 23 Dec 20].
- Morihara N et al. Garlic as an anti-fatigue agent. Mol Nutr Food Res. 2007 Nov;51(11):1329-34. doi: 10.1002/mnfr.200700062. PMID: 17955479.
- Morihara, Naoaki et al. (2006). Aged Garlic Extract Ameliorates Physical Fatigue. Biological & pharmaceutical bulletin. 29. 962-6. 10.1248/bpb.29.962.
- Tsai, Shih-Jen Aged garlic extract supplement helps relieve acute stress, Journal of the Chinese Medical Association: September 2019 - Volume 82 - Issue 9 - p 677-678 doi: 10.1097/JCMA.0000000000000142
- Gala, Thaddeus R, and David R Seaman. “Lifestyle modifications and the resolution of obstructive sleep apnea syndrome: a case report.” Journal of chiropractic medicine vol. 10,2 (2011): 118-25. doi:10.1016/j.jcm.2010.12.003