Honeysuckle

Immune Support
Honeysuckle is rich in immune-boosting antioxidants, polyphenols, and polysaccharides (1). Studies show that honeysuckle also supports the immune system by reversing immunosuppression and stimulating immune factors like tumor necrosis factor-α and IL-2 (2). 

Research also indicates that honeysuckle may be helpful in fighting certain viral and microbial infections (3, 4). 


Reduces Inflammation
Studies indicate that honeysuckle has anti-inflammatory effects, largely due to it’s up-regulation of tumor necrosis factor-α, COX-2, and IL-2 (5). 


Allergy Support
Studies show that honeysuckle can reduce inflammatory reactions and moderate the autoimmune response in conditions like allergic rhinitis (6).

Respiratory Support
Honeysuckle is rich in polyphenols which may help to improve lung function. Studies show that blue honeysuckles extract can reduce lung fibrosis by modulating the immune response (7). 


Gut Health Support
Honeysuckle’s anti-inflammatory effects have been shown to reduce symptoms related to inflammatory bowel diseases like IBS and colitis (8).

Heart Support
Studies show that honeysuckle has a vasodilatory effect that can help to reduce high blood pressure, reduce the risk of cardiovascular disease, and improve heart health (9). 


Energy Support
No evidence found.

Mood Support
Studies suggest that honeysuckle may benefit those with depression. In studies, honeysuckle extracts and polysaccharides show neuroprotective effects by inhibiting the NLRP3-inflammasome which may be implicated in mood disorders (10). 

 


Sleep Support
No evidence found.

 

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REFERENCES:

 

  1. Kucharska, Alicja Z et al. “Iridoids, Phenolic Compounds and Antioxidant Activity of Edible Honeysuckle Berries (Lonicera caerulea var. kamtschatica Sevast.).” Molecules (Basel, Switzerland) vol. 22,3 405. 5 Mar. 2017, doi:10.3390/molecules22030405

 

  1. So-Jin Kim et al, HS-23, a Lonicera japonica extract, reverses sepsis-induced immunosuppression by inhibiting lymphocyte apoptosis, Journal of Ethnopharmacology, Volume 171, 2015, Pages 231-239, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2015.05.049.

 

  1. Ying-Ray Lee et al, Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis, Journal of Ethnopharmacology, Volume 198, 2017, Pages 109-121, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2016.12.049.

 

  1. Ying-Ray Lee et al, Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis, Journal of Ethnopharmacology, Volume 198, 2017, Pages 109-121, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2016.12.049.

 

  1. Nikzad-Langerodi R et al. Assessment of anti-inflammatory properties of extracts from Honeysuckle (Lonicera sp. L., Caprifoliaceae) by ATR-FTIR spectroscopy. Talanta. 2017 Dec 1;175:264-272. doi: 10.1016/j.talanta.2017.07.045. Epub 2017 Jul 18. PMID: 28841989.

 

  1. Lin, Bin et al. “Honeysuckle extract relieves ovalbumin-induced allergic rhinitis by inhibiting AR-induced inflammation and autoimmunity.” Bioscience reports vol. 39,7 BSR20190673. 29 Jul. 2019, doi:10.1042/BSR20190673

 

  1. Jin Zhao et al, Polyphenol-rich blue honeysuckle extract alleviates silica-induced lung fibrosis by modulating Th immune response and NRF2/HO-1 MAPK signaling, Journal of Functional Foods, Volume 53, 2019, Pages 176-186, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2018.12.030.
  2. Park, Jae-Woo et al. (2012). Prophylactic effects of Lonicera japonica extract on dextran sulphate sodium-induced colitis in a mouse model by the inhibition of the Th1/Th17 response. The British journal of nutrition. 109. 1-10. 10.1017/S0007114512001122. 

 

  1. Bell, L., Williams, C.M. A pilot dose–response study of the acute effects of haskap berry extract (Lonicera caerulea L.) on cognition, mood, and blood pressure in older adults. Eur J Nutr 58, 3325–3334 (2019). https://doi.org/10.1007/s00394-018-1877-9

 

  1. Liu, Ping et al. “The protective effect of Lonicera japonica polysaccharide on mice with depression by inhibiting NLRP3 inflammasome.” Annals of translational medicine vol. 7,24 (2019): 811. doi:10.21037/atm.2019.12.64