Andrographis may have a significant immune support, specifically for fighting infections and managing cancer. Studies show that andrographis has targeted anti-cancer activity on various human cancers, stimulates lymphocyte proliferation, and produces interleukin-2 (1). Other studies show that andrographis may cause cancer cell-cycle arrest at G0/G1 by inducing inhibitory proteins to slow the development of cancer (2).
Andrographis paniculata, AP3, has also been deemed a potentially cost-effective treatment to treat covid-19 infections in developing countries (3).
Andrographolides are compounds specific to andrographis with strong anti-inflammatory effects. Studies show that andrographolides reduce inflammatory by enhancing immune function and stimulating T cells, natural killer cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (4).
Other studies indicate that andrographis has strong anti-inflammatory effects which are achieved by interfering with COX and inflammatory cytokines, as well as modifying the expression genes that are involved in the inflammatory cascade (5, 6).
Clinical trials indicate that andrographis can offer prophylaxis and symptomatic relief for respiratory infections like the common cold, sinusitis, and others (11). Other studies concur that andrographis is effective for treating upper respiratory tract infections, and particularly helpful for improving symptoms related to the throat (12).
Studies show andrographis helps to manage allergies and chronic sinus infections by enhancing immune function and reducing inflammation in the sinuses and upper respiratory tract (10).
Studies show that andrographolides have a positive and protective effect on the central nervous system. Results indicate that andrographis moderates serum cortisol levels and may help manage stress, mood imbalances, and other cognitive issues (15).
Studies show that andrographolide acts as an adaptogen, and can help to reduce stress-triggered physiological responses (16). This is closely related to improving sleep disruption and insomnia.