Zinc is required for a healthy gut microbiome. Studies suggest that zinc can improve the composition of the microbiome, decrease inflammation in the gut, and improve overall gut physiology (12).
Low zinc levels are correlated with a higher risk of cardiovascular disease (8). Experimental studies suggest that zinc supplementation can improve myocardial recovery, reduce hypertension, and decrease the risk of arrhythmias (9).
Zinc may also play an important role in diabetes management. Zinc is required for β-cell function, insulin action, and glucose homeostasis. Research indicates that supplementation may enhance insulin sensitivity and prevent diabetes, as well as stroke and other cardiovascular conditions that result from unmanaged blood sugar and obesity (10). Both in vivo and in vitro studies show beneficial effects of zinc supplementation for type-1 and type-2 diabetes (11).
Studies show a strong correlation between zinc deficiency and depressive symptoms, as well as an improvement in mood and reduction in depression in those supplementing with zinc (14).
Astragalus may help those with chronic fatigue as it has been shown to improve feelings of fatigue and tiredness (17).
Studies suggest that astragalus can help fight fatigue and improve extreme tiredness, especially in those undergoing chemotherapy (18). Studies suggest that zinc may help reduce or prevent fatigue in those undergoing chemotherapy (13).
Zinc is required for healthy skin integrity and barrier function. As such, zinc supplementation might be beneficial for those with skin allergies like atopic dermatitis and eczema (5).
Research shows that zinc acts as a “sleep modulator,” potentially managing the sleep-wake cycle, improving the quality of sleep, and enhancing overall brain function (15).