Zinc

Immune Support
Zinc is an essential micronutrient that is needed for a healthy immune response. Zinc deficiency is tied to cell-mediated immune dysfunction, increased inflammation, and damage to healthy tissues (1). Research suggests that supplementing with zinc may help to improve the immune response (2).


Reduces Inflammation
Studies show that zinc deficiency may reduce the body’s ability to moderate proinflammatory factors like interleukin 6 (3). Chronic zinc deficiency may lead to chronic systemic inflammation and the development of inflammatory diseases like diabetes and dementia (4).

Allergy Support
Zinc is required for a healthy skin integrity and barrier function. As such, zinc supplementation might be beneficial for those with skin allergies like atopic dermatitis and eczema (5).

Respiratory Support
Zinc has a protective effect on the respiratory system. Studies show that zinc deficiency can contribute to respiratory conditions like asthma and allergic rhinitis (6). Other studies show that zinc can lower airway inflammation and improve breathing abilities in those with asthma (7).

Heart Support
Low zinc levels are correlated with a higher risk of cardiovascular disease (8). Experimental studies suggest that zinc supplementation can improve myocardial recovery, reduce hypertension, and decrease risk of arrhythmias (9).

Zinc may also play an important role in diabetes management. Zinc is required for β-cell function, insulin action, and glucose homeostasis. Research indicates that supplementation may enhance insulin sensitivity and prevent diabetes, as well as stroke and other cardiovascular conditions that result from unmanaged blood sugar and obesity (10). Both in vivo and in vitro studies show beneficial effects of zinc supplementation for type-1 and type-2 diabetes (11).

Gut Health Support
Zinc is required for a healthy gut microbiome. Studies suggest that zinc has the ability to improve the composition of the microbiome, decrease inflammation in the gut, and improve overall gut physiology (12).


Energy Support
Studies suggest that zinc may help reduce or prevent fatigue in those undergoing chemotherapy (13). 

 

Mood Support
Studies show a strong correlation between zinc deficiency and depressive symptoms, as well as an improvement in mood and reduction in depression in those supplementing with zinc (14).


Sleep Support
Research shows that zinc acts as a “sleep modulator,” potentially managing the sleep-wake cycle, improving the quality of sleep, and enhancing overall brain function (15). 

 

 -----

REFERENCES:

 

  1. Gammoh, Nour Zahi, and Lothar Rink. “Zinc in Infection and Inflammation.” Nutrients vol. 9,6 624. 17 Jun. 2017, doi:10.3390/nu9060624

 

  1. Mocchegiani, Eugenio et al. “Zinc: dietary intake and impact of supplementation on immune function in elderly.” Age (Dordrecht, Netherlands) vol. 35,3 (2013): 839-60. doi:10.1007/s11357-011-9377-3

 

  1. Gammoh, Nour Zahi, and Lothar Rink. “Zinc in Infection and Inflammation.” Nutrients vol. 9,6 624. 17 Jun. 2017, doi:10.3390/nu9060624

 

  1. Nuttall, Johnathan R, and Patricia I Oteiza. “Zinc and the aging brain.” Genes & nutrition vol. 9,1 (2014): 379. doi:10.1007/s12263-013-0379-x

 

  1. Gray NA et al. Zinc and atopic dermatitis: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2019 Jun;33(6):1042-1050. doi: 10.1111/jdv.15524. Epub 2019 Mar 15. PMID: 30801794.

 

  1. Djuric, V. et al. (2005). Zinc and copper in serum and induced sputum of patients with allergic rhinitis and allergic asthma. Allergologie. 28. 165-171. 

 

  1. Morgan, Carrie I et al. “Zinc supplementation alters airway inflammation and airway hyperresponsiveness to a common allergen.” Journal of inflammation (London, England) vol. 8 36. 7 Dec. 2011, doi:10.1186/1476-9255-8-36

 

  1. Chu, Anna et al. “Zinc Status and Risk of Cardiovascular Diseases and Type 2 Diabetes Mellitus-A Systematic Review of Prospective Cohort Studies.” Nutrients vol. 8,11 707. 5 Nov. 2016, doi:10.3390/nu8110707

 

  1. Milton, Abul Hasnat et al. “Prospective Study of Dietary Zinc Intake and Risk of Cardiovascular Disease in Women.” Nutrients vol. 10,1 38. 4 Jan. 2018, doi:10.3390/nu10010038

 

  1. El Dib  R et al. Zinc supplementation for the prevention of type 2 diabetes mellitus in adults with insulin resistance. Cochrane Database of Systematic Reviews 2015, Issue 5. Art. No.: CD005525. DOI: 10.1002/14651858.CD005525.pub3. Accessed 23 December 2020.

 

  1. Ranasinghe, Priyanga et al. “Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications.” Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences vol. 23,1 44. 17 Sep. 2015, doi:10.1186/s40199-015-0127-4

 

  1. Sauer, Ann Katrin, and Andreas M Grabrucker. “Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice.” Frontiers in neuroscience vol. 13 1295. 29 Nov. 2019, doi:10.3389/fnins.2019.01295

 

  1. Ribeiro, Sofia Miranda de Figueiredo et al. “Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer.” Einstein (Sao Paulo, Brazil) vol. 15,1 (2017): 24-28. doi:10.1590/S1679-45082017AO3830

 

  1. Wang, Jessica et al. “Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications.” Nutrients vol. 10,5 584. 9 May. 2018, doi:10.3390/nu10050584

 

  1. Cherasse, Yoan, and Yoshihiro Urade. “Dietary Zinc Acts as a Sleep Modulator.” International journal of molecular sciences vol. 18,11 2334. 5 Nov. 2017, doi:10.3390/ijms18112334